Host-range shift of H3N8 canine influenza virus: a phylodynamic analysis of its origin and adaptation from equine to canine host
Identifieur interne : 000023 ( Main/Exploration ); précédent : 000022; suivant : 000024Host-range shift of H3N8 canine influenza virus: a phylodynamic analysis of its origin and adaptation from equine to canine host
Auteurs : Wanting He [République populaire de Chine] ; Gairu Li ; Ruyi Wang ; Weifeng Shi ; Kemang Li ; Shilei Wang ; Alexander Lai ; Shuo SuSource :
- Veterinary Research [ 0928-4249 ] ; 2019-12.
Abstract
Prior to the emergence of H3N8 canine influenza virus (CIV) and the latest avian-origin H3N2 CIV, there was no evidence of a circulating canine-specific influenza virus. Molecular and epidemiological evidence suggest that H3N8 CIV emerged from H3N8 equine influenza virus (EIV). This host-range shift of EIV from equine to canine hosts and its subsequent establishment as an enzootic CIV is unique because this host-range shift was from one mammalian host to another. To further understand this host-range shift, we conducted a comprehensive phylodynamic analysis using all the available whole-genome sequences of H3N8 CIV. We found that (1) the emergence of H3N8 CIV from H3N8 EIV occurred in approximately 2002; (2) this interspecies transmission was by a reassortant virus of the circulating Florida-1 clade H3N8 EIV; (3) once in the canine species, H3N8 CIV spread efficiently and remained an enzootic virus; (4) H3N8 CIV evolved and diverged into multiple clades or sublineages, with intra and inter-lineage reassortment. Our results provide a framework to understand the molecular basis of host-range shifts of influenza viruses and that dogs are potential “mixing vessels” for the establishment of novel influenza viruses.
Url:
DOI: 10.1186/s13567-019-0707-2
Affiliations:
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Molecular and epidemiological evidence suggest that H3N8 CIV emerged from H3N8 equine influenza virus (EIV). This host-range shift of EIV from equine to canine hosts and its subsequent establishment as an enzootic CIV is unique because this host-range shift was from one mammalian host to another. To further understand this host-range shift, we conducted a comprehensive phylodynamic analysis using all the available whole-genome sequences of H3N8 CIV. We found that (1) the emergence of H3N8 CIV from H3N8 EIV occurred in approximately 2002; (2) this interspecies transmission was by a reassortant virus of the circulating Florida-1 clade H3N8 EIV; (3) once in the canine species, H3N8 CIV spread efficiently and remained an enzootic virus; (4) H3N8 CIV evolved and diverged into multiple clades or sublineages, with intra and inter-lineage reassortment. Our results provide a framework to understand the molecular basis of host-range shifts of influenza viruses and that dogs are potential “mixing vessels” for the establishment of novel influenza viruses.</p> </div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Lai, Alexander" sort="Lai, Alexander" uniqKey="Lai A" first="Alexander" last="Lai">Alexander Lai</name><name sortKey="Li, Gairu" sort="Li, Gairu" uniqKey="Li G" first="Gairu" last="Li">Gairu Li</name><name sortKey="Li, Kemang" sort="Li, Kemang" uniqKey="Li K" first="Kemang" last="Li">Kemang Li</name><name sortKey="Shi, Weifeng" sort="Shi, Weifeng" uniqKey="Shi W" first="Weifeng" last="Shi">Weifeng Shi</name><name sortKey="Su, Shuo" sort="Su, Shuo" uniqKey="Su S" first="Shuo" last="Su">Shuo Su</name><name sortKey="Wang, Ruyi" sort="Wang, Ruyi" uniqKey="Wang R" first="Ruyi" last="Wang">Ruyi Wang</name><name sortKey="Wang, Shilei" sort="Wang, Shilei" uniqKey="Wang S" first="Shilei" last="Wang">Shilei Wang</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="He, Wanting" sort="He, Wanting" uniqKey="He W" first="Wanting" last="He">Wanting He</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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